Title

The Numerical Design of a Parallel Plate Flow Chamber for Investigation of Endothelial Cell Response to Shear Stress

Document Type

Article

Publication Date

5-1-2003

Abstract

Parallel plate chambers are frequently used to examine the response of biological cells to a constant wall shear stress. However, the stress can vary more than 80% across the chamber due to end effects. Earlier estimates of the magnitude of this inhomogeneity used boundary layer theory and experiments. Here, the full equations for steady, three-dimensional flow in a novel parallel plate device were solved numerically and used to identify an active test region where the shear stress is within 5% of a constant value. Endothelial cells can be confined to this region to assure a nearly uniform shear stress exposure.

DOI

10.1016/S0045-7949(02)00416-9

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