Title

The Development of Novel and Selective P56(Lck) Tyrosine Kinase Inhibitors

Document Type

Article

Publication Date

9-22-1998

Abstract

Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

DOI

10.1016/S0960-894X(98)00445-4

This document is currently not available here.

Share

COinS