The Development of Novel and Selective P56(Lck) Tyrosine Kinase Inhibitors
Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).
MSU Digital Commons Citation
Bullington, James L.; Cameron, Julie C.; Davis, Janet E.; Dodd, John H.; Harris, Crafford A.; Henry, James R.; Pellegrino-Gensey, J. Lee; Rupert, Kenneth C.; and Siekierka, John, "The Development of Novel and Selective P56(Lck) Tyrosine Kinase Inhibitors" (1998). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 116.