The Development of Novel and Selective P56(Lck) Tyrosine Kinase Inhibitors
Document Type
Article
Publication Date
9-22-1998
Abstract
Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).
DOI
10.1016/S0960-894X(98)00445-4
Montclair State University Digital Commons Citation
Bullington, James L.; Cameron, Julie C.; Davis, Janet E.; Dodd, John H.; Harris, Crafford A.; Henry, James R.; Pellegrino-Gensey, J. Lee; Rupert, Kenneth C.; and Siekierka, John, "The Development of Novel and Selective P56(Lck) Tyrosine Kinase Inhibitors" (1998). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 116.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/116
Published Citation
Bullington, J. L., Cameron, J. C., Davis, J. E., Dodd, J. H., Harris, C. A., Henry, J. R., ... & Siekierka, J. J. (1998). The development of novel and selective p56lck tyrosine kinase inhibitors. Bioorganic & medicinal chemistry letters, 8(18), 2489-2494.