Title

Natural Product Analogues: Towards a Blueprint for Analogue-Focused Synthesis

Document Type

Article

Publication Date

8-21-2017

Abstract

For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.

DOI

10.1039/c6cs00842a

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