Synthesis of L-4,4-Difluoroglutamic Acid Via Electrophilic Difluorination of a Lactam
(matrix presented) An enantiomerically pure bicyclic lactam proved to be an excellent substrate for electrophilic difluorination using N-fluorobenzenesulfonimide. The resulting difluorinated lactam can be easily converted into L-4,4-difluoroglutamic acid. To the best of our knowledge, this is the first example of a synthetically useful electrophilic difluorination of an unactivated lactam.
MSU Digital Commons Citation
Konas, David and Coward, James K., "Synthesis of L-4,4-Difluoroglutamic Acid Via Electrophilic Difluorination of a Lactam" (1999). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 17.