The Effect of Pyrrolo[3,4-C]Carbazole Derivatives on Spinal Cord Chat Activity
Pyrrolo[3,4-c]carbazole derivatives were prepared as potential neurotrophic agents. The compounds were assayed for their ability to stimulate choline acetyltransferase (ChAT) activity in embryonic rat spinal cord cultures. These simplified K252a derivatives, although less potent and efficacious, have led to the identification of minimal structural requirements for K252a neurotrophic activity.
MSU Digital Commons Citation
Rotella, David; Glicksman, Marcie A.; Prantner, J. Eric; Neff, Nicola T.; and Hudkins, Robert L., "The Effect of Pyrrolo[3,4-C]Carbazole Derivatives on Spinal Cord Chat Activity" (1995). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 241.