Potent Inhibitors of the MAP Kinase p38
The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
MSU Digital Commons Citation
Henry, James R.; Rupert, Kenneth C.; Dodd, John H.; Turchi, Ignatius J.; Wadsworth, Scott A.; Cavender, Druie E.; Schafer, Peter H.; and Siekierka, John, "Potent Inhibitors of the MAP Kinase p38" (1998). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 359.