Title

Potent Inhibitors of the MAP Kinase p38

Document Type

Article

Publication Date

12-1-1998

Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

DOI

10.1016/S0960-894X(98)00589-7

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