Stereoselective Synthesis of Erythro Α-Amino Epoxides
The stereoselective reduction of bromomethyl ketones derived from leucine, phenylalanine, alanine and valine is described using borohydride reagents. The Boc-amino alcohol product has erythro stereochemistry at the carbinol center as deduced by conversion to Boc-amino epoxides. These oxiranes are useful for the preparation of hydroxyethylene peptide isosteres.
MSU Digital Commons Citation
Rotella, David, "Stereoselective Synthesis of Erythro Α-Amino Epoxides" (1995). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 394.