Title

Potent Non-Nitrile Dipeptidic Dipeptidyl Peptidase IV Inhibitors

Document Type

Article

Publication Date

12-1-2007

Abstract

The synthesis and structure-activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β-branched natural and unnatural amino acids, particularly adamantylglycines, linked to a (2S,3R)-2,3-methanopyrrolidine based scaffold.

DOI

10.1016/j.bmcl.2007.09.090

This document is currently not available here.

Share

COinS