Nitroarylhydroxymethylphosphonic Acids As Inhibitors of CD45
Document Type
Article
Publication Date
12-1-1997
Abstract
A series of nitroarylhydroxymethylphosphonic acids was synthesized and evaluated as inhibitors of CD45. It was discovered that both the alpha hydroxy and nitro groups are essential for activity. Potency is enhanced by the addition of a large lipophilic group on the aryl ring adjacent to the phosphonic acid moiety. Kinetics studies have shown that these compounds are competitive inhibitors and thus bind at the active site of this enzyme.
DOI
10.1016/S0968-0896(97)00174-0
Montclair State University Digital Commons Citation
Beers, Scott A.; Malloy, Elizabeth A.; Wu, Wei; Wachter, Michael P.; Gunnia, Uma; Cavender, Druie; Harris, Crafford; Davis, Janet; Brosius, Ruth; Pellegrino-Gensey, J. Lee; and Siekierka, John, "Nitroarylhydroxymethylphosphonic Acids As Inhibitors of CD45" (1997). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 50.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/50