Date of Award
Master of Science (MS)
College of Science and Mathematics
Chemistry and Biochemistry
Thesis Sponsor/Dissertation Chair/Project Chair
S. A. de Silva
J. L. Isidor
M. A. Whitener
Two new second generation fluorescent switches that are based on the chromophore-spacer-receptor architecture are reported in this thesis. The fluorescence modulation of these switches is a result of quenching or initiating photoinduced electron transfer (PET) between the chromophore and the receptors due to cation binding. These two molecules utilize an alkaloid, anabasine, as the proton receptor, and function as fluorescent off-on-off switches with decreasing pH. One of these molecules also utilizes a coumarin as the chromophore, making it the first rationally designed fluorescent PET system based on natural products. Further studies of two well-known first generation fluorescent switches to achieve more complex fluorescence modulation are also reported in this thesis.
Loo, Kenny, "Fluorescent Photoinduced Electron Transfer (PET) Cation Sensors Derived from Natural Products" (2005). Theses, Dissertations and Culminating Projects. 1195.