Date of Award
Master of Science (MS)
College of Science and Mathematics
Thesis Sponsor/Dissertation Chair/Project Chair
Sandra D. Adams
Lee H. Lee
Quinn C. Vega
Herpes simplex virus, Antiviral agents
Herpes simplex virus type 1 (HSV-1) is a linear double stranded DNA virus that is responsible for one of the most common sexually transmitted diseases within the United States. However, treatment drugs for HSV-1 could be costly and may have side effects. In recent years the number of cases of drug resistant HSV-1 has increased, resulting in interest for novel treatments. This study aimed to investigate the antiviral effects of the reagent Embelin on HSV-1 infection in cultured Vero Cells. Embelin is a benzoquinone isolated from the plant Embelia ribes. Cell viability and cell proliferation assays were conducted to determine the maximum noncytotoxic concentration of Embelin. Additional assays were conducted to measure cell proliferation and antiviral effect. The results of this study suggest that Embelin indeed inhibits HSV-1 with best viral inhibition between 50 μM and 54 μM. Also, Embelin seems to be most effective at inhibiting the virus at the binding stage of the viral cycle.
Elias, Tony, "The Antiviral Effects of Embelin on HSV-1 in Cultured Vero Cells" (2020). Theses, Dissertations and Culminating Projects. 513.
Available for download on Tuesday, December 08, 2020