Characterizing Functions of Two Regulatory Proteins in the Parasitic Nematode Brugia malayi and Their Potential as Drug Targets in Treating Lymphatic Filariasis
Date of Award
Master of Science (MS)
College of Science and Mathematics
Chemistry and Biochemistry
Thesis Sponsor/Dissertation Chair/Project Chair
Lymphatic filariasis (LF) is a debilitating disease caused by parasitic nematodes that affect millions of people in largely tropical environments. While drugs are available for treating LF, they suffer from a lack of efficacy against adult parasites, toxicity, and emergence of resistance. Here, we describe two novel potential drug targets within the filarial parasite, Brugia malayi (B. malayi). These two proteins, bm9350, a predictive MAPK stress response protein, and bm2032, a potential histone modifying enzyme, have little or no annotation or experimental evidence of function. Using predictive analysis and tools, we examined potential functions of these proteins and their potential as anti-filarial drug targets.
Hart, Brittany Amber, "Characterizing Functions of Two Regulatory Proteins in the Parasitic Nematode Brugia malayi and Their Potential as Drug Targets in Treating Lymphatic Filariasis" (2020). Theses, Dissertations and Culminating Projects. 631.