Core Temperature Influences On the Relationship Between Exercise-Induced Leukocytosis and Cortisol Or TNF-Α
Introduction: The extent to which exercise in the heat modifies leukocytosis and the relationship between the leukocytosis and tumor necrosis factor-alpha (TNF-α) or cortisol is not well understood. Thus, this study attempted to determine the combined effect of exercise and differing elevations in core temperature on exercise-induced leukocytosis and to examine associations between any leukocytosis and cortisol or TNF-α. Methods: Eight male subjects completed two 40-min trials while immersed in 25 and 38.5°C water. Leukocytes, TNF-α, and cortisol were determined at baseline, immediately post-, and 2 h post-exercise. Results: Both trials resulted in significant 13-33% increases in total leukocytes, mostly driven by a 24-30% increase in neutrophils. A significant relationship was found between the change in core temperature (Tre) during exercise and the increase in total leukocytes (r = 0.561). Similarly, the change in Tre was related to the change in cortisol (r = 0.557) and TNF-α (r = 0.483). Yet the exercise-induced change in cortisol was not significantly correlated to any changes in leukocytes. There was a trend for the relationships between the exercise-induced change in TNF-α and the changes in total leukocytes (r = 0.491) and neutrophils (r = 0.479). Discussion: These results suggest that although neither cortisol nor TNF-α are strong predictors of the leukocyte response during exercise or recovery, each factor may be one of many potential modifiers of the total leukocyte response.
MSU Digital Commons Citation
Cooper, Erica S.; Berry, Mark P.; McMurray, Robert G.; Hosick, Peter; and Hackney, Anthony C., "Core Temperature Influences On the Relationship Between Exercise-Induced Leukocytosis and Cortisol Or TNF-Α" (2010). Department of Exercise Science and Physical Education Scholarship and Creative Works. 16.