The Effect of Immobilization and Dietary Phosphorus on Bone Density of Mature Female Rats
The right femurs of adult female rats were bound to their chests over a 14 week period. During this time rats were fed diets providing adequate calcium (Ca) and adequate (0.4%) or high (1.2%) phosphorus (P). Rats fed the high P diet tended to lose more weight during the experimental period than rats fed the adequate P diet. Both immobilization and a high P diet significantly reduced bone density. Thin cortical widths of rats fed the high P diet were apparently due to an increased medullary width rather than to a decreased subperiosteal width, while the reverse was true for the immobilized femur as compared to that of the mobile limb. A high P diet greatly increased the concentration of Ca and P in the kidney.
MSU Digital Commons Citation
Bauer, Kathleen and Griminger, Paul, "The Effect of Immobilization and Dietary Phosphorus on Bone Density of Mature Female Rats" (1985). Department of Nutrition and Food Studies Scholarship and Creative Works. 98.