Methylphenidate-Induced Conditioned Taste Aversions: An Index of Toxicity

Document Type

Article

Publication Date

1-1-1978

Journal / Book Title

Psychobiology

Abstract

Following consumption of saccharin, groups of rats were injected with various doses of methylphenidate hydrochloride. Small aversions were found after one conditioning trial, with repeated saccharin-methlyphenidate pairings resulting in continued decrements in consumption. The strength of the aversion as well as the amount of individual variability were dose-related, with weaker aversions and greater individual variability occurring at the smaller dose (15 mg/kg). Although aversions were quite pronounced at higher doses, individual variability, although small, was still evident. The similarities and differences between methylphenidate-induced aversions and aversions based on emetics were discussed, along with the implications of these results as indices for methylphenidate-induced toxicity.

DOI

10.3758/BF03326737

Published Citation

Riley, A.L., Zellner, D.A. Methylphenidate-induced conditioned taste aversions: An index of toxicity. Psychobiology 6, 354–358 (1978). https://doi.org/10.3758/BF03326737

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