Journal / Book Title
Health Education & Behavior
This article compares four mixed-model analyses valid for group-randomized trials (GRTs) involving a nested cohort design with a single pretest and posttest. This study makes estimates of intraclass correlations (ICCs) available to investigators planning GRTs addressing dietary outcomes. It also provides formulae demonstrating the potential benefits to the standard error of the intervention effect (σΔ) from adjustments for both fixed and time-varying covariates and correlations over time. These estimates will allow other researchers to use these variables to plan their studies by estimating a priori detectable differences and sample size requirements for any of the four analytic options. These methods are demonstrated using data from the Teens Eating for Energy and Nutrition at School study. Mixed-model analyses of covariance proved to be the most powerful analysis in that data set. The formulae may be applied to any dependent variable in any GRT given corresponding information for those variables on the parameters that define the formulae.
MSU Digital Commons Citation
Janega, Jessica B.; Murray, David M.; Varnell, Sherri P.; Blitstein, Jonathan L.; Birnbaum, Amanda; and Lytle, Leslie A., "Assessing Intervention Effects in a School-Based Nutrition Intervention Trial: Which Analytic Model Is Most Powerful?" (2004). Department of Public Health Scholarship and Creative Works. 188.
Janega, Jessica B., David M. Murray, Sherri P. Varnell, Jonathan L. Blitstein, Amanda S. Birnbaum, and Leslie A. Lytle. "Assessing intervention effects in a school-based nutrition intervention trial: Which analytic model is most powerful?." Health Education & Behavior 31, no. 6 (2004): 756-774. Harvard
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