Document Type


Publication Date

Summer 8-2005

Journal / Book Title

Cancer Epidemiology, Biomarkers & Prevention


An increasing number of studies are focusing on the potential association between dietary folate intake and risk of various cancers (1), particularly of the colorectum and breast (2, 3). A low folate status can induce misincorporation of uracil into DNA, leading to chromosome breaks in humans and hence increasing cancer risk (4). Alcohol may increase folate requirements in the body and cause relative folate deficiencies (2). Although several findings on the relation between folate intake and ovarian cancer risk are inconsistent (5-9), recent results from two prospective studies, including 266 and 147 incident cases of epithelial ovarian cancer, have suggested an interaction of folate and alcohol in ovarian carcinogenesis [i.e., folate would be inversely related to ovarian cancer risk in alcohol drinkers (5, 6), and alcohol in those with high folate intake (7)]. With the aim to provide further data on the issue, we assessed the relation between dietary folate, alcohol consumption, and ovarian cancer risk in a multicentric case-control study conducted in Italy (10).


DOI: 10.1158/1055-9965.EPI-05-0192

Published Citation

Pelucchi, Claudio, Monia Mereghetti, Renato Talamini, Eva Negri, Maurizio Montella, Valerio Ramazzotti, Silvia Franceschi, and Carlo La Vecchia. "Dietary folate, alcohol consumption, and risk of ovarian cancer in an Italian case-control study." Cancer Epidemiology and Prevention Biomarkers 14, no. 8 (2005): 2056-2058.