In-vitro analysis of cobalt sulfate exposure on human fibroblast lung cell health
Presentation Type
Abstract
Faculty Advisor
Ann Dilorenzo
Access Type
Event
Start Date
25-4-2025 10:30 AM
End Date
25-4-2025 11:29 AM
Description
The rapid shift toward sustainable energy solutions, particularly in the transportation sector, has driven a surge in electric vehicle (EV) production. As the demand for EVs continues to rise, so does the global reliance on cobalt mining and its subsequent use in commercial applications despite the long-term health consequences of increased cobalt exposure remaining largely unclear. An in vitro study using cobalt sulfate to induce toxicity was used to investigate the effect this toxin had on cellular proliferation and other cellular processes in a MRC-5 cell line. Preliminary results show that increasing cobalt sulfate toxicity concentrations have a negative impact on cellular morphology. Additionally, a half-maximal inhibitory concentration (IC50) of 0.09 mM CoSO4 was determined and used for future experiments. CoSO4 toxicity has a negative effect on the cell line and future work seeks to understand what cellular processes are being affected and whether or not these cells can be salvaged after toxicity.
In-vitro analysis of cobalt sulfate exposure on human fibroblast lung cell health
The rapid shift toward sustainable energy solutions, particularly in the transportation sector, has driven a surge in electric vehicle (EV) production. As the demand for EVs continues to rise, so does the global reliance on cobalt mining and its subsequent use in commercial applications despite the long-term health consequences of increased cobalt exposure remaining largely unclear. An in vitro study using cobalt sulfate to induce toxicity was used to investigate the effect this toxin had on cellular proliferation and other cellular processes in a MRC-5 cell line. Preliminary results show that increasing cobalt sulfate toxicity concentrations have a negative impact on cellular morphology. Additionally, a half-maximal inhibitory concentration (IC50) of 0.09 mM CoSO4 was determined and used for future experiments. CoSO4 toxicity has a negative effect on the cell line and future work seeks to understand what cellular processes are being affected and whether or not these cells can be salvaged after toxicity.
Comments
Poster presentation at the 2025 Student Research Symposium.