Reactive Oxygen Species and Nitric Oxide Mediate Plasticity of Neuronal Calcium Signaling
Document Type
Article
Publication Date
1-4-2000
Abstract
Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca2+ signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca2+ signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.
DOI
10.1073/pnas.97.1.448
Montclair State University Digital Commons Citation
Petroff, Elena; Brot, Nathan; Weissbach, Herbert; Heinemann, Stefan H.; and Hoshi, Toshinori, "Reactive Oxygen Species and Nitric Oxide Mediate Plasticity of Neuronal Calcium Signaling" (2000). Department of Biology Faculty Scholarship and Creative Works. 231.
https://digitalcommons.montclair.edu/biology-facpubs/231