Adrenergic Signals Direct Rhythmic Expression of Transcriptional Represser CREM in the Pineal Gland

Authors

Jërg H. Stehle, CNRS
Nicholas S. Foulkes, Université de Strasbourg
Carlos Molina, Montclair State UniversityFollow
Valérie Simonneaux, CNRS
Paul Pévet, CNRS
Paolo Sassone-Corsi, University of California, Irvine

Document Type

Article

Publication Date

1-1-1993

Journal / Book Title

Nature

Abstract

Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.

DOI

10.1038/365314a0

Montclair State University Digital Commons Citation

Stehle, Jërg H.; Foulkes, Nicholas S.; Molina, Carlos; Simonneaux, Valérie; Pévet, Paul; and Sassone-Corsi, Paolo, "Adrenergic Signals Direct Rhythmic Expression of Transcriptional Represser CREM in the Pineal Gland" (1993). Department of Biology Faculty Scholarship and Creative Works. 351.
https://digitalcommons.montclair.edu/biology-facpubs/351

Published Citation

Stehle, J., Foulkes, N., Molina, C. et al. Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland. Nature 365, 314–320 (1993). https://doi.org/10.1038/365314a0