Adrenergic Signals Direct Rhythmic Expression of Transcriptional Represser CREM in the Pineal Gland
Document Type
Article
Publication Date
1-1-1993
Journal / Book Title
Nature
Abstract
Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.
DOI
10.1038/365314a0
Montclair State University Digital Commons Citation
Stehle, Jërg H.; Foulkes, Nicholas S.; Molina, Carlos; Simonneaux, Valérie; Pévet, Paul; and Sassone-Corsi, Paolo, "Adrenergic Signals Direct Rhythmic Expression of Transcriptional Represser CREM in the Pineal Gland" (1993). Department of Biology Faculty Scholarship and Creative Works. 351.
https://digitalcommons.montclair.edu/biology-facpubs/351
Published Citation
Stehle, J., Foulkes, N., Molina, C. et al. Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland. Nature 365, 314–320 (1993). https://doi.org/10.1038/365314a0