Document Type
Article
Publication Date
4-1-2001
Journal / Book Title
Breast Cancer Research
Abstract
We examined lysosomal participation in the degradation of tumor cells from human breast biopsies, utilizing the histochemical activity and localization of acid phosphatase (AP). Enzyme activities in benign and malignant lesions were compared. AP was faintly detected in normal mammary epithelia and was marked in malignant cells. The histochemical patterns of AP distribution in the breast tissues showed differences between normal and neoplastic cells. AP staining was more intense in ductal carcinoma in situ (DCIS) associated with invasive ductal carcinoma (IDC) cases compared to when IDC was present alone. These results suggest that non-invasive breast cancers, such as DCIS, may be subjected to more lysosomal cellular lysis than is observed in invasive breast cancers, like IDC.
DOI
10.1186/bcr296
Montclair State University Digital Commons Citation
Halaby, Reginald; Abdollahi, Jafar; and Martinez, Minerva L., "Acid Phosphatase Activity in Human Breast Tumors" (2001). Department of Biology Faculty Scholarship and Creative Works. 373.
https://digitalcommons.montclair.edu/biology-facpubs/373
Published Citation
Halaby, R., Abdollahi, J., & Martinez, M. L. (2001). Acid phosphatase activity in human breast tumors. Breast Cancer Research, 3(2), 1-7.