Complexity and Versatility of the Transcriptional Response to Camp
Document Type
Article
Publication Date
1-1-1994
Journal / Book Title
Reviews of Physiology, Biochemistry and Pharmacology
Abstract
The large number of CRE binding proteins reveals the complexity of the cellular response to cAMP and possibly suggests the requirements of cell-specificity and potential cross-talk mechanisms with the PKC pathway. The CREM gene constitutes a paradigm that represents another level of complexity. Its modularity of function, which is mediated by alternative and cell-specific splicing events, is an example of the versatility that the cell must accomplish in order to permit normal and regulated cell growth in response to several stimuli. The generation of CREB/CREM-deficent animals by homologous recombination will be an important step in the determination of the precise roles played by the different CRE binding proteins in vivo.
DOI
10.1007/BFb0031030
Montclair State University Digital Commons Citation
Delmas, V.; Molina, Carlos; Lalli, Enzo; de Groot, R.; Foulkes, N. S.; Masquilier, D.; and Sassone-Corsi, P., "Complexity and Versatility of the Transcriptional Response to Camp" (1994). Department of Biology Faculty Scholarship and Creative Works. 411.
https://digitalcommons.montclair.edu/biology-facpubs/411
Published Citation
Delmas, V. et al. (1994). Complexity and versatility of the transcriptional response to cAMP. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 124. Reviews of Physiology, Biochemistry and Pharmacology, vol 124. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0031030
