Document Type
Article
Publication Date
1-27-2022
Journal / Book Title
Pathogens
Abstract
The coxsackievirus and adenovirus receptor (CAR) is an essential cellular protein that is involved in cell adhesion, cell signaling, and viral infection. The 8-exon encoded isoform (CAREx8) resides at the apical surface of polarized epithelia, where it is accessible as a receptor for adenovirus entering the airway lumen. Given its pivotal role in viral infection, it is a target for antiviral strategies. To understand the regulation of CAREx8 and determine the feasibility of receptor down regulation, the half-life of total and apical localized CAREx8 was determined and correlated with adenovirus transduction. Total and apical CAREx8 has a relatively short half-life of approximately 2 h. The half-life of apical CAREx8 correlates well with adenovirus transduction. These results suggest that antiviral strategies that aim to degrade the primary receptor for apical adenovirus infection will be effective within a relatively short time frame after application.
DOI
10.3390/pathogens11020173
Montclair State University Digital Commons Citation
Kotha Lakshmi Narayan, Poornima; Readler, James M.; Alghamri, Mahmoud S.; Brockman, Trisha L.; Yan, Ray; Sharma, Priyanka; Snitsarev, Vladislav; Excoffon, Katherine J.D.A; and Kolawole, Abimbola O., "The Coxsackievirus and Adenovirus Receptor Has a Short Half-Life in Epithelial Cells" (2022). Department of Biology Faculty Scholarship and Creative Works. 451.
https://digitalcommons.montclair.edu/biology-facpubs/451
Published Citation
Kotha Lakshmi Narayan, P., Readler, J. M., Alghamri, M. S., Brockman, T. L., Yan, R., Sharma, P., Snitsarev, V., Excoffon, K. J. D. A., & Kolawole, A. O. (2022). The Coxsackievirus and Adenovirus Receptor Has a Short Half-Life in Epithelial Cells. Pathogens, 11(2), 173. https://doi.org/10.3390/pathogens11020173
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Comments
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).