Document Type
Article
Publication Date
11-10-2021
Journal / Book Title
Medicines
Abstract
Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine the ability of some natural products to induce lysosomal-mediated cell death in neoplastic cells as a way to kill them more specifically than conventional therapies. This list is by no means exhaustive. We postulate mechanisms to explain lysosomal membrane permeabilization and its role in triggering cell death in cancer cells.
DOI
10.3390/medicines8110069
Montclair State University Digital Commons Citation
Halaby, Reginald, "Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy" (2021). Department of Biology Faculty Scholarship and Creative Works. 582.
https://digitalcommons.montclair.edu/biology-facpubs/582
Rights
© 2021 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Published Citation
Halaby, R. (2021). Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy. Medicines, 8(11), 69. https://doi.org/10.3390/medicines8110069