Mono- and Di-2,2,2-Trichloroethyl Acetals as Protecting Groups

Authors

John Isidor, Montclair State UniversityFollow
Robert M. Carlson, University of MinnesotaFollow

Document Type

Article

Publication Date

2-1-1973

Abstract

Mono- and di-2,2,2-trichloroethyl acetals have been selectively prepared in good yields by acid-catalyzed alcohol exchange with 2,2,2-trichloroethanol and dimethyl or diethyl acetals. A nonacidic and aprotic reductive cleavage using activated zinc dust in ethyl acetate or THE regenerates the carbonyl.

DOI

10.1021/jo00943a030

Montclair State University Digital Commons Citation

Isidor, John and Carlson, Robert M., "Mono- and Di-2,2,2-Trichloroethyl Acetals as Protecting Groups" (1973). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 193.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/193