Mono- and Di-2,2,2-Trichloroethyl Acetals as Protecting Groups
Mono- and di-2,2,2-trichloroethyl acetals have been selectively prepared in good yields by acid-catalyzed alcohol exchange with 2,2,2-trichloroethanol and dimethyl or diethyl acetals. A nonacidic and aprotic reductive cleavage using activated zinc dust in ethyl acetate or THE regenerates the carbonyl.
MSU Digital Commons Citation
Isidor, John and Carlson, Robert M., "Mono- and Di-2,2,2-Trichloroethyl Acetals as Protecting Groups" (1973). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 193.