Radioiodination of Interleukin 2 to High Specific Activities by the Vapor-Phase Chloramine T Method
Recombinant human interleukin 2 (IL-2) was radioiodinated utilizing the vapor phase chloramine T method of iodination. The method is rapid, reproducible, and allows the efficient radioiodination of IL-2 to specific activities higher than those previously attained with full retention of biological activity. IL-2 radioiodinated by this method binds with high affinity to receptors present on phytohemagglutinin-stimulated peripheral blood lymphocytes and should be useful for the study of receptor structure and function.
MSU Digital Commons Citation
Siekierka, John and DeGudicibus, Steven, "Radioiodination of Interleukin 2 to High Specific Activities by the Vapor-Phase Chloramine T Method" (1988). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 251.