Efficient Soluble Polymer-Supported Tartrate/Ti Catalyst for Asymmetric Oxidation of Prochiral Sulfides

Document Type

Article

Publication Date

11-26-2007

Abstract

A group of soluble polymer-supported chiral tartrate ligands was prepared by liquid-phase synthesis with ligand diversity strategy. Moderate to excellent chemical yields and enantiomeric excesses were obtained by using soluble polymer-supported tartrate ester in asymmetric oxidation of prochiral sulfides using Ti(O-i-Pr)4/cumyl hydroperoxide, and the workup was greatly simplified. The influence of substituent in chiral tartrate ligands on the enantioselectivities of the reaction was disclosed.

DOI

10.1016/j.tetlet.2007.09.169

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