"Direct Determination of Kinetic Rates from Single-Molecule Photon Arri" by Michael Andrec, Ronald M. Levy et al.
 

Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

Document Type

Article

Publication Date

9-25-2003

Journal / Book Title

The Journal of Physical Chemistry A

Abstract

The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

DOI

10.1021/jp035514+

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