Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

Authors

Michael Andrec, Rutgers - The State University of New Jersey, New Brunswick
Ronald M. Levy, Rutgers - The State University of New Jersey, New Brunswick
David Talaga, Montclair State UniversityFollow

Document Type

Preprint

Publication Date

9-25-2003

Journal / Book Title

The Journal of Physical Chemistry A

Abstract

The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

DOI

10.1021/jp035514+

Montclair State University Digital Commons Citation

Andrec, Michael; Levy, Ronald M.; and Talaga, David, "Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models" (2003). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 350.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/350

Published Citation

Published in final edited form as: J Phys Chem A. 2003 September 3; 107(38): 7454–7464. doi:10.1021/jp035514+.