Silver Effect in Regiodivergent Gold-Catalyzed Hydroaminations
We report a silver-induced switching of regioselectivity in gold-catalyzed reactions, and we provide mechanistic evidence to suggest a true "silver effect": that is, one that is implicated in the catalytic process itself, via σ-gold π-silver acetylides. These results are of significance because they clearly show that the use of silver as halide abstractors in gold-catalyzed reactions may result in "silver effects" when terminal alkyne substrates are involved.
10.1021/acscatal.9b00249Final published version Open
MSU Digital Commons Citation
Veguillas, Marcos; Rosair, Georgina M.; Bebbington, Magnus; and Lee, Ai Lan, "Silver Effect in Regiodivergent Gold-Catalyzed Hydroaminations" (2019). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 496.