Information Theoretical Approach to Single-Molecule Experimental Design and Interpretation
Document Type
Article
Publication Date
8-10-2006
Journal / Book Title
The Journal of Physical Chemistry A
Abstract
We use Shannon's definition of information to develop a theory to predict a photon-counting-based single-molecule experiment's ability to measure the desired property. We treat three phenomena that are commonly measured on single molecules: spectral fluctuations of a solvatochromic dye; assignment of the azimuthal dipole angle; determination of a distance by fluorescence resonant energy transfer using Förster's theory. We consider the effect of background and other "imperfections" on the measurement through the decrease in information.
DOI
10.1021/jp062192b
Montclair State University Digital Commons Citation
Talaga, David, "Information Theoretical Approach to Single-Molecule Experimental Design and Interpretation" (2006). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 533.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/533
