Information Theoretical Approach to Single-Molecule Experimental Design and Interpretation
We use Shannon's definition of information to develop a theory to predict a photon-counting-based single-molecule experiment's ability to measure the desired property. We treat three phenomena that are commonly measured on single molecules: spectral fluctuations of a solvatochromic dye; assignment of the azimuthal dipole angle; determination of a distance by fluorescence resonant energy transfer using Förster's theory. We consider the effect of background and other "imperfections" on the measurement through the decrease in information.
MSU Digital Commons Citation
Talaga, David, "Information Theoretical Approach to Single-Molecule Experimental Design and Interpretation" (2006). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 533.