Document Type
Article
Publication Date
2-3-2021
Journal / Book Title
Frontiers in Microbiology
Abstract
The primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P. falciparum PKG (PfPKG) as a drug target for treating and/or protecting against malaria. PfPKG is essential in the asexual erythrocytic and sexual cycles as well as the pre-erythrocytic cycle. Medicinal chemistry efforts, both target-based and phenotype-based, have targeted PfPKG in the past few years. This review provides a brief overview of their results and challenges.
DOI
10.3389/fmicb.2020.610408
Montclair State University Digital Commons Citation
Rotella, David; Siekierka, John; and Bhanot, Purnima, "Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target" (2021). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 641.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/641
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Published Citation
Rotella, D., Siekierka, J., & Bhanot, P. (2021). Plasmodium falciparum cGMP-Dependent Protein Kinase - A Novel Chemotherapeutic Target. Frontiers in microbiology, 11, 610408. https://doi.org/10.3389/fmicb.2020.610408