Document Type
Article
Publication Date
1-30-2026
Journal / Book Title
ACS Medicinal Chemistry Letters
Abstract
Previous work demonstrated target engagement with an orally bioavailable, potent, selective PDE11A4 inhibitor in the mouse hypothalamus. This compound was limited by low aqueous solubility, stimulating the need for alternative leads with improved pharmaceutical properties to carry out efficacy studies. This paper outlines optimization of a pyrrolopyrimidine hit leading to a potent, selective PDE11A4 inhibitor with improved pharmaceutical properties and promising activity in cell-based models of enzyme activity.
DOI
10.1021/acsmedchemlett.5c00756
Montclair State University Digital Commons Citation
Mahmood, Shams ul; Boddu, Rama Krishna; Eberhard, Jeremy; Hoffman, Charles S.; Gordon, John; Colussi, Dennis; Childers, Wayne; Amurrio, Elvis; Danaher, Marie; Kelly, Michy P.; and Rotella, David P., "Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties" (2026). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 653.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/653
Rights
This publication is licensed under CC-BY 4.0.
Published Citation
Mahmood, Shams Ul, et al. “Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties.” ACS Medicinal Chemistry Letters, vol. 17, no. 2, Feb. 2026, pp. 547–53. https://doi.org/10.1021/acsmedchemlett.5c00756.