Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase

Authors

• Shams ul Mahmood, Montclair State UniversityFollow
• Huimin Cheng, Montclair State UniversityFollow
• Sreedhar R. Tummalapalli, Montclair State UniversityFollow
• Ramappa Chakrasali, Montclair State UniversityFollow
• Rammohan R. Yadav Bheemanaboina, Montclair State UniversityFollow
• Tamara Kreiss, Montclair State UniversityFollow
• Agnieszka Chojnowski, Montclair State UniversityFollow
• Tyler Eck, Montclair State UniversityFollow
• John J. Siekierka, Montclair State UniversityFollow
• David P. Rotella, Montclair State UniversityFollow

Document Type

Article

Publication Date

12-16-2019

Journal / Book Title

RSC Medicinal Chemistry

Abstract

The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors.

DOI

10.1039/C9MD00511K

Montclair State University Digital Commons Citation

Mahmood, Shams ul; Cheng, Huimin; Tummalapalli, Sreedhar R.; Chakrasali, Ramappa; Yadav Bheemanaboina, Rammohan R.; Kreiss, Tamara; Chojnowski, Agnieszka; Eck, Tyler; Siekierka, John J.; and Rotella, David P., "Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase" (2019). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 655.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/655

Published Citation

Mahmood, Shams Ul, et al. “Discovery of Isoxazolyl-Based Inhibitors of Plasmodium Falciparum cGMP-Dependent Protein Kinase.” RSC Medicinal Chemistry, vol. 11, no. 1, 2020, pp. 98–101. https://doi.org/10.1039/C9MD00511K.