"Quantitative Preventive Approaches to Diabetes: Mathematical Modeling " by Rushi P. Bhatt

Date of Award

1-2025

Document Type

Thesis

Degree Name

Master of Science (MS)

College/School

College of Science and Mathematics

Department/Program

School of Computing

Thesis Sponsor/Dissertation Chair/Project Chair

Baojun Song

Committee Member

David Trubatch

Committee Member

Charles Du

Abstract

The rising prevalence of diabetes presents a pressing global health concern, necessitating effective control strategies. This study aims to construct a mathematical model to analyze the influence of diverse factors on blood sugar levels, with a focus on identifying optimal methods for maintaining healthy glucose levels. Employing ordinary differential equations (ODE), the model investigates variables including leptin resistance, fat mass, glucose, insulin resistance, beta cell mass, daily physical activity, and dietary intake. Utilizing parameter estimates from existing literature, the model’s framework is established, and simulation results elucidate the intricate interplay between lifestyle choices and blood glucose dynamics. Furthermore, the model evaluates the effectiveness of preventive interventions in blood sugar regulation and diabetes prevention. This research emphasizes the importance of adopting a holistic approach to diabetes prevention, encompassing regular exercise, balanced nutrition, and proactive management of risk factors.

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