Date of Award

5-2012

Document Type

Thesis

Degree Name

Master of Science (MS)

College/School

College of Science and Mathematics

Department/Program

Biology

Thesis Sponsor/Dissertation Chair/Project Chair

Sandra Adams

Committee Member

Ann Marie DiLorenzo

Committee Member

Lee Lee

Abstract

Tea is a highly consumed beverage with numerous health benefits, such as antioxidant and antiviral properties. The compounds within tea that are believed to be associated with these benefits are polyphenols. Black tea polyphenols are known as theaflavins, and in previous studies have exhibited inhibitory effects on influenza and human immunodeficiency virus 1. Herpes simplex virus -1 (HSV-1) is an extremely common virus and has the ability to cause recurrent infections. A vast majority of adults have been exposed to the virus and could be asymptomatic. The purpose of this study was to determine the lowest inhibitory concentration of black tea extracts on the herpes simplex virus -1. Utilizing plaque assays, DNA extraction, PCR, and gel electrophoresis, it was determined that viral inhibition occurs at a concentration of 0.1 ug/mL BTE.

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