Biliverdin Reductase Isozymes In Metabolism

Authors

Luke O'Brien, University of Toledo
Peter Hosick, Montclair State University
Kezia John, University of Toledo
David E. Stec, University of Mississippi
Terry D. Hinds, University of Toledo

Document Type

Review Article

Publication Date

1-1-2015

Journal / Book Title

Trends in Endocrinology & Metabolism

Abstract

The biliverdin reductase (BVR) isozymes BVRA and BVRB are cell surface membrane receptors with pleiotropic functions. This review compares, for the first time, the structural and functional differences between the isozymes. They reduce biliverdin, a byproduct of heme catabolism, to bilirubin, display kinase activity, and BVRA, but not BVRB, can act as a transcription factor. The binding motifs present in the BVR isozymes allow a wide range of interactions with components of metabolically important signaling pathways such as the insulin receptor kinase cascades, protein kinases (PKs), and inflammatory mediators. In addition, serum bilirubin levels have been negatively associated with abdominal obesity and hypertriglyceridemia. We discuss the roles of the BVR isozymes in metabolism and their potential as therapeutic targets.

DOI

10.1016/j.tem.2015.02.001

Montclair State University Digital Commons Citation

O'Brien, Luke; Hosick, Peter; John, Kezia; Stec, David E.; and Hinds, Terry D., "Biliverdin Reductase Isozymes In Metabolism" (2015). Department of Exercise Science and Physical Education Scholarship and Creative Works. 7.
https://digitalcommons.montclair.edu/exersci-physed-facpubs/7