Document Type
Article
Publication Date
3-11-2017
Journal / Book Title
International Journal of Molecular Sciences
Abstract
Induction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created an adipose-specific HO-1 knockout mouse model. Male and female mice were fed either a control or a high-fat diet for 30 weeks. Body weights were measured weekly and body composition, fasting blood glucose and insulin levels were determined every six weeks. Adipocyte-specific knockout of HO-1 had no significant effect on body weight in mice fed a high-fat diet but increased body weight in female mice fed a normal-fat diet. Although body weights were not different in females fed a high fat diet, loss of HO-1 in adipocytes resulted in significant alterations in body composition. Adipose-specific HO-1 knockout resulted in increased fasting hyperglycemia and insulinemia in female but not male mice on both diets. Adipose-specific knockout of HO-1 resulted in a significant loss of HO activity and a decrease in the protein levels of adiponectin in adipose tissue. These results demonstrate that loss of HO-1 in adipocytes has greater effects on body fat and fasting hyperglycemia in a sex-dependent fashion and that expression of HO-1 in adipose tissue may have a greater protective role in females as compared to males.
DOI
https://doi.org/10.3390/ijms18030611
Montclair State University Digital Commons Citation
Hosick, Peter A.; Weeks, Mary Frances; Hankins, Michael W.; Moore, Kyle H.; and Stec, David E., "Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice" (2017). Department of Exercise Science and Physical Education Scholarship and Creative Works. 86.
https://digitalcommons.montclair.edu/exersci-physed-facpubs/86
Published Citation
Hosick, Peter A., Mary Frances Weeks, Michael W. Hankins, Kyle H. Moore, and David E. Stec. "Sex-dependent effects of HO-1 deletion from adipocytes in mice." International Journal of Molecular Sciences 18, no. 3 (2017): 611.
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