Document Type
Article
Publication Date
10-10-1996
Journal / Book Title
Journal of Biological Chemistry
Abstract
Glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-β family of growth factors, was first identified by its ability to promote the survival of midbrain dopaminergic neurons in culture. We demonstrate that GDNF treatment of several neuroblastoma cell lines leads to dose-dependent tyrosine phosphorylation of the RET receptor and that other transforming growth factor-β family members are not able to activate the RET receptor. GDNF treatment of neuroblastoma cells also results in increased transcription of an Elk luciferase reporter gene, suggesting that GDNF activates the mitogen-activated protein kinase signal transduction pathway.
DOI
10.1074/jbc.271.39.23619
MSU Digital Commons Citation
Worby, Carolyn A.; Vega, Quinn C.; Zhao, Yi; Chao, Hanna H.; Seasholtz, Audrey F.; and Dixon, Jack E., "Glial Cell Line-Derived Neurotrophic Factor Signals Through the RET Receptor and Activates Mitogen-Activated Protein Kinase" (1996). Department of Mathematics Facuty Scholarship and Creative Works. 84.
https://digitalcommons.montclair.edu/mathsci-facpubs/84
Published Citation
Worby, C. A., Vega, Q. C., Zhao, Y., Chao, H. H., Seasholtz, A. F., & Dixon, J. E. (1996). Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. The Journal of biological chemistry, 271(39), 23619–23622. https://doi.org/10.1074/jbc.271.39.23619
Comments
This is an open access article distributed under the terms of the Creative Commons CC-BY 4.0 license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.