Effect of Weight Loss by Diet or Gastric Bypass Surgery on Peptide YY3-36 Levels

Authors

Blanca Oliván, Columbia UniversityFollow
Julio Teixeira, St. Luke's-Roosevelt Hospital CenterFollow
Mousumi Bose, Montclair State UniversityFollow
Baani Bawa, Vanderbilt University Medical CenterFollow
Tangel Chang, Columbia University
Heather Summe, Columbia University
Hongchan Lee, Columbia University
Blandine Laferrère, Columbia UniversityFollow

Document Type

Article

Publication Date

6-1-2009

Journal / Book Title

Annals of Surgery

Abstract

Objective: To examine the effect of an equivalent weight loss, by gastric bypass surgery (GBP) or by diet, on peptide YY3-36 (PYY3-36), ghrelin, and leptin levels and to determine the effect of diabetes status on PYY3-36 levels. SUMMARY BACKGROUND DATA:: The increased PYY3-36 levels after GBP may be involved in the magnitude and the sustainability of weight loss after surgery. METHODS:: Of the 30 morbidly obese women who participated in the study, 21 had type 2 diabetes mellitus, and were studied before and after equivalent weight loss of 10 kg by either GBP (n = 11) or by diet (n = 10). RESULTS:: PYY3-36 levels were higher in obese diabetic as compared with nondiabetic individuals (64.1 ± 34.4 pg/mL vs. 39.9 ± 21.1 pg/mL; P < 0.05). PYY3-36 levels increased markedly in response to oral glucose after GBP (peak: 72.3 ± 20.5 pg/mL-132.7 ± 49.7 pg/mL; P < 0.001; AUC0-180: 51.5 ± 23.3 pg/mL.min-91.1 ± 32.2 pg/mL.min P < 0.001), but not after diet (peak: 85.5 ± 51.9 pg/mL-84.8 ± 41.13 pg/mL; P = NS; AUC0-180: 68.3 ± 38.5 pg/mL.min-61.1 ± 42.2 pg/mL.min P = NS). Fasting ghrelin levels increased after diet (425 ± 91 pg/mL-519 ± 105 pg/mL; P < 0.05), but did not change after GBP (506 ± 121 pg/mL-482 ± 196 pg/mL; P = NS). CONCLUSIONS:: Diabetes status seems to be a determinant of PYY3-36 levels. GBP, but not diet-induced weight loss, resulted in markedly increased glucose-stimulated PYY3-36 levels. The increase in stimulated PYY3-36 levels after GBP is likely a result of the surgery rather than a secondary outcome of weight loss. Changes in PYY3-36 levels and ghrelin could contribute to the success of GBP in sustaining weight loss.

DOI

10.1097/SLA.0b013e3181a6cdb0

MSU Digital Commons Citation

Oliván, Blanca; Teixeira, Julio; Bose, Mousumi; Bawa, Baani; Chang, Tangel; Summe, Heather; Lee, Hongchan; and Laferrère, Blandine, "Effect of Weight Loss by Diet or Gastric Bypass Surgery on Peptide YY3-36 Levels" (2009). Department of Nutrition and Food Studies Scholarship and Creative Works. 46.
https://digitalcommons.montclair.edu/nutr-foodstudies-facpubs/46