Inhibition of Intestinal Tumorigenesis in Apcmin/+ Mice by Green Tea Polyphenols (Polyphenon E) and Individual Catechins

Authors

Xingpei Hao, Rutgers - The State University of New Jersey, NewarkFollow
Mousumi Bose, Montclair State UniversityFollow
Joshua D. Lambert, Rutgers - The State University of New Jersey, NewarkFollow
Jihyeung Ju, Rutgers - The State University of New Jersey, NewarkFollow
Gang Lu, Rutgers - The State University of New Jersey, Newark
Mao Jung Lee, Rutgers - The State University of New Jersey, New BrunswickFollow
Sunny Park, Rutgers - The State University of New Jersey, NewarkFollow
Ali Husain, Rutgers - The State University of New Jersey, Newark
Steven Wang, Rutgers - The State University of New Jersey, NewarkFollow
Yuhai Sun, Rutgers - The State University of New Jersey, New Brunswick
Chung S. Yang, Rutgers - The State University of New Jersey, New BrunswickFollow

Document Type

Article

Publication Date

1-1-2007

Abstract

In this work, we compared the cancer preventive activities of Polyphenon E (PPE), a standardized green tea polyphenol preparation given in diet versus drinking fluid as well as the activities of PPE versus individual catechins. We treated ApcMin/+ mice for 9 wk with 0.08% (-)-epigallocatechin-3- gallate (EGCG), 0.08% (-)-epicatechin-3-gallate, or 0.12% PPE in drinking fluid or diet. Only 0.12% dietary PPE and 0.08% EGCG in drinking fluid significantly decreased tumor multiplicity (70% and 51%, respectively). Compared to PPE in drinking fluid, dietary PPE delivered twofold more EGCG to the small intestine. Immunohistochemistry showed that adenomas in groups treated with PPE and EGCG had decreased cell proliferation, β-catenin nuclear expression, and phospho-Akt levels; higher cleaved caspase-3 levels, and partially restored retinoid X receptor a expression. The results suggest that these molecular events contribute to the cancer prevention activity of EGCG and PPE. Furthermore, diet appears to be a better route of administration for PPE than drinking fluid.

DOI

10.1080/01635580701365050

MSU Digital Commons Citation

Hao, Xingpei; Bose, Mousumi; Lambert, Joshua D.; Ju, Jihyeung; Lu, Gang; Lee, Mao Jung; Park, Sunny; Husain, Ali; Wang, Steven; Sun, Yuhai; and Yang, Chung S., "Inhibition of Intestinal Tumorigenesis in Apcmin/+ Mice by Green Tea Polyphenols (Polyphenon E) and Individual Catechins" (2007). Department of Nutrition and Food Studies Scholarship and Creative Works. 64.
https://digitalcommons.montclair.edu/nutr-foodstudies-facpubs/64