Title

Chinese Herb Extract Induces Apoptosis Triggered by Lysosomes in MCF-7 Cells

Presentation Type

Event

Start Date

27-4-2019 8:45 AM

End Date

27-4-2019 9:25 AM

Abstract

Triptolide is a woody vine widely distributed in Eastern and Southern China with bioactive component from Triptergium Wilfordii Hook F. The component has been shown to have anticancer effects by inducing apoptosis in various tumor cells.

Breast cancer is the second deadliest cancer among women in the United States, as the National Cancer Institute estimates that one in seven women living in the United States will develop breast cancer in their lifetime. They majority of the conventional cancer treatment protocols are nonspecific, namely killing tumor cells as well as healthy cells. The design of targeted, safer anticancer agents is prevalent.

In this study, we demonstrate the effect of triptolide on MCF-7 cells, which were examined to determine triptolide its ability to induce lysosomal-mediated apoptotic cell death in MCF-7 cells because they lack caspase-3.

These findings are significant because results warrant further investigation of triptolide’s potential as an anticancer therapeutic agent. Our study provides a mechanism that may be used to develop breast cancer therapies wherein triptolide sensitizes resistant breast cancer cells to cell death.

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Apr 27th, 8:45 AM Apr 27th, 9:25 AM

Chinese Herb Extract Induces Apoptosis Triggered by Lysosomes in MCF-7 Cells

Triptolide is a woody vine widely distributed in Eastern and Southern China with bioactive component from Triptergium Wilfordii Hook F. The component has been shown to have anticancer effects by inducing apoptosis in various tumor cells.

Breast cancer is the second deadliest cancer among women in the United States, as the National Cancer Institute estimates that one in seven women living in the United States will develop breast cancer in their lifetime. They majority of the conventional cancer treatment protocols are nonspecific, namely killing tumor cells as well as healthy cells. The design of targeted, safer anticancer agents is prevalent.

In this study, we demonstrate the effect of triptolide on MCF-7 cells, which were examined to determine triptolide its ability to induce lysosomal-mediated apoptotic cell death in MCF-7 cells because they lack caspase-3.

These findings are significant because results warrant further investigation of triptolide’s potential as an anticancer therapeutic agent. Our study provides a mechanism that may be used to develop breast cancer therapies wherein triptolide sensitizes resistant breast cancer cells to cell death.