Title

The Effects of Triptolide on Mitochondrial Stability in MCF-7 Cells

Presentation Type

Event

Start Date

27-4-2019 8:45 AM

End Date

27-4-2019 9:25 AM

Abstract

Breast cancer is one of the most pervasive cancers among women globally. However, its demographic expands much further; also affecting men and transgender individuals from various racial and ethnic backgrounds. The effects of Triptolide, on mitochondrial localization and membrane permeabilization in MCF-7 cells, were observed and assessed through the use of MitoTracker Green and fluorescence microscopy. Mitochondria were observed in the nuclear regions of experimental cells while they remained in the cytosol of control cells. Triptolide appeared to cause depolarization of the mitochondrial membrane. These findings support the conclusion that Triptolide assists in MCF-7 apoptosis through mitochondrial outer membrane permeabilization (MOMP). These results allow Triptolide to be considered as viable option to traditional cancer treatments.

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Apr 27th, 8:45 AM Apr 27th, 9:25 AM

The Effects of Triptolide on Mitochondrial Stability in MCF-7 Cells

Breast cancer is one of the most pervasive cancers among women globally. However, its demographic expands much further; also affecting men and transgender individuals from various racial and ethnic backgrounds. The effects of Triptolide, on mitochondrial localization and membrane permeabilization in MCF-7 cells, were observed and assessed through the use of MitoTracker Green and fluorescence microscopy. Mitochondria were observed in the nuclear regions of experimental cells while they remained in the cytosol of control cells. Triptolide appeared to cause depolarization of the mitochondrial membrane. These findings support the conclusion that Triptolide assists in MCF-7 apoptosis through mitochondrial outer membrane permeabilization (MOMP). These results allow Triptolide to be considered as viable option to traditional cancer treatments.