Title

Quasiracemates of Copper Complexes of N-Benzoylalanine with Nitrogen Heterocyclic Ligands

Presentation Type

Event

Start Date

27-4-2019 8:45 AM

End Date

27-4-2019 9:24 AM

Abstract

Crystals are solids with a three dimensional repeating pattern of atoms or molecules Some molecules come in right and left handed forms which often crystallize with center of symmetry. This is a racemate. This research plans to study quasiracemates, which are two chemically distinct compounds that have opposite handedness that often pack into crystals with a pseudo-center of symmetry. The two compounds in the quasiracemate are of similar shape, but one group is chemically different.

We chose to study metal complexes with differently substituted N-benzoylalanate ligands [C6H5-C=O-NH-C(H)(CH3)(COO-)]. The metal provides the center point to arrange the two chiral molecules in a pseudo-symmetric arrangement. We plan to use copper as our metal center. We will use substituted benzoylalanines as the right and left handed molecules. Benzoylalanines are synthesized by reaction of benzoyl chlorides with alanine.

As a preliminary study, to test the feasibility of preparing quasiracemates, we investigated copper complexes with unsubstituted benzoylalanine with or without various nitrogen ligands (imidazole, N-methylimidazole, and pyridine). These complexes are racimates not quasiracemates. We have prepared several derivatives and their crystal structures will be discussed.

Future studies will include the investigation of substituted benzoylalanines which will be quasiracemates which have different substituents on the right and left handed molecules. From these studies, we seek to understand the importance of shape in how molecules pack in crystal structures.

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Apr 27th, 8:45 AM Apr 27th, 9:24 AM

Quasiracemates of Copper Complexes of N-Benzoylalanine with Nitrogen Heterocyclic Ligands

Crystals are solids with a three dimensional repeating pattern of atoms or molecules Some molecules come in right and left handed forms which often crystallize with center of symmetry. This is a racemate. This research plans to study quasiracemates, which are two chemically distinct compounds that have opposite handedness that often pack into crystals with a pseudo-center of symmetry. The two compounds in the quasiracemate are of similar shape, but one group is chemically different.

We chose to study metal complexes with differently substituted N-benzoylalanate ligands [C6H5-C=O-NH-C(H)(CH3)(COO-)]. The metal provides the center point to arrange the two chiral molecules in a pseudo-symmetric arrangement. We plan to use copper as our metal center. We will use substituted benzoylalanines as the right and left handed molecules. Benzoylalanines are synthesized by reaction of benzoyl chlorides with alanine.

As a preliminary study, to test the feasibility of preparing quasiracemates, we investigated copper complexes with unsubstituted benzoylalanine with or without various nitrogen ligands (imidazole, N-methylimidazole, and pyridine). These complexes are racimates not quasiracemates. We have prepared several derivatives and their crystal structures will be discussed.

Future studies will include the investigation of substituted benzoylalanines which will be quasiracemates which have different substituents on the right and left handed molecules. From these studies, we seek to understand the importance of shape in how molecules pack in crystal structures.