ICER-Ilγ Is a Tumor Suppressor that Mediates the Antiproliferative Activity of Camp
Document Type
Article
Publication Date
12-10-1998
Abstract
The second messenger cAMP inhibits the proliferation of most cell types. The nuclear response of cAMP is mediated by transcription factors like the cAMP-Responsive Element Modulator (CREM) gene. One of the products of the CREM gene, the transcriptional repressor Inducible cAMP Early Repressor-IIγ (ICER-IIγ), is induced by cAMP. ICER-IIγ blocks cells at the G2/M boundary of the cell cycle. Here we show that ICER-IIγ dramatically inhibits the growth and DNA synthesis of mouse pituitary tumor cells and human choriocarcinoma cells. This alteration in cell growth is coupled with reduced ability of these cells to grow in an anchorage-independent manner and to form tumors in mice. These data demonstrate that ICER-IIγ is a tumor suppressor gene product mediating the antiproliferative activity of cAMP.
DOI
10.1038/sj.onc.1202225
Montclair State University Digital Commons Citation
Razavi, Reza; Ramos, Juan C.; Yehia, Ghassan; Schlotter, Florence; and Molina, Carlos, "ICER-Ilγ Is a Tumor Suppressor that Mediates the Antiproliferative Activity of Camp" (1998). Department of Biology Faculty Scholarship and Creative Works. 325.
https://digitalcommons.montclair.edu/biology-facpubs/325