Study and Modulation of Human Cortical Excitability with Transcranial Magnetic Stimulation

Authors

Alvaro Pascual-Leone, University of Valencia
Jose M. Tormos, Harvard University
Julian Keenan, Montclair State UniversityFollow
Francisco Tarazona, University of Valencia
Carlos Cañete, University of Valencia
Maria D. Catalá, University of Valencia

Document Type

Article

Publication Date

1-1-1998

Journal / Book Title

Journal of Clinical Neurophysiology

Abstract

Transcranial magnetic stimulation (TMS) can be applied in different paradigms to obtain a measure of various aspects of cortical excitability. These different TMS paradigms provide information about different neurotransmitter systems, enhance our understanding about the pathophysiology of neuropsychiatric conditions, and in the future may be helpful as a guide for pharmacological interventions. In addition, repetitive TMS (rTMS) modulates cortical excitability beyond the duration of the rTMS trains themselves. Depending on rTMS parameters, a lasting inhibition or facilitation of cortical excitability can be induced. These effects can be demonstrated neurophysiologically or by combining rTMS with neuroimaging techniques. The effects do not remain limited to the cortical area directly targeted by rTMS, but affect a wider neural network transynaptically. Modulation of cortical excitability by rTMS may in the future be useful not only as a research tool but also as a therapeutic intervention in neurology, psychiatry, and neurorehabilitation.

DOI

10.1097/00004691-199807000-00005

Montclair State University Digital Commons Citation

Pascual-Leone, Alvaro; Tormos, Jose M.; Keenan, Julian; Tarazona, Francisco; Cañete, Carlos; and Catalá, Maria D., "Study and Modulation of Human Cortical Excitability with Transcranial Magnetic Stimulation" (1998). Department of Biology Faculty Scholarship and Creative Works. 349.
https://digitalcommons.montclair.edu/biology-facpubs/349

Published Citation

Pascual-Leone, A., Tormos, J. M., Keenan, J., Tarazona, F., Cañete, C., & Catalá, M. D. (1998). Study and modulation of human cortical excitability with transcranial magnetic stimulation. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 15(4), 333–343. https://doi.org/10.1097/00004691-199807000-00005