Alkyl Ether Derivatives of the FK-506 Related, Immunosuppressive Macrolide L-683,742 (C31-O-Desmethyl Ascomycin)

Authors

Mark T. Goulet, Merck
Derek W. Hodkey, Merck
Mary Jo Staruch, MerckFollow
Francis J. Dumont, Université de StrasbourgFollow
C. Shirley Lin, MerckFollow
Shirley H Y Hung, Merck
John Siekierka, Montclair State UniversityFollow
Matthew J. Wyvratt, MerckFollow

Document Type

Article

Publication Date

1-1-1994

Journal / Book Title

Bioorganic & Medicinal Chemistry Letters

Abstract

Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.

DOI

10.1016/S0960-894X(01)80265-1

Montclair State University Digital Commons Citation

Goulet, Mark T.; Hodkey, Derek W.; Staruch, Mary Jo; Dumont, Francis J.; Lin, C. Shirley; Hung, Shirley H Y; Siekierka, John; and Wyvratt, Matthew J., "Alkyl Ether Derivatives of the FK-506 Related, Immunosuppressive Macrolide L-683,742 (C31-O-Desmethyl Ascomycin)" (1994). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 123.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/123