Three Distinct Human Thymopoietins are derived from Alternatively Spliced mRNAs
Document Type
Article
Publication Date
7-5-1994
Abstract
Thymopoietin (TP) was originally isolated as a 5-kDa 49-aa protein from bovine thymus in studies of the effects of thymic extracts on neuromuscular transmission and was subsequently observed to affect T-cell differentiation and function. We now report the isolation of cDNA clones for three alternatively spliced mRNAs that encode three distinct human T-cell TPs. Proteins encoded by these mRNAs, which we have named TPα (75 kDa), TPβ (51 kDa), and TPγ (39 kDa), contain identical N-terminal regions, including sequences nearly identical to that of the originally isolated 49-aa protein, but divergent C-terminal regions. TP mRNAs are expressed in many tissues, most abundantly in adult thymus and fetal liver of the tissues so far examined. Distinct structural domains and functional motifs in TPs α, β, and γ suggest that the proteins have unique functions and may be directed to distinct subcellular compartments.
DOI
10.1073/pnas.91.14.6283
Montclair State University Digital Commons Citation
Harris, Crafford A.; Andryuk, Paula J.; Cline, Scott; Chan, H. Karen; Natarajan, Anan; Siekierka, John; and Goldstein, Gideon, "Three Distinct Human Thymopoietins are derived from Alternatively Spliced mRNAs" (1994). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 414.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/414